Inhalation powder
The result of the magic triangle of excipients, blending and filling processes
Maschinen- und Anlagenbau
2. Materials and Methods and Analytics
3. Results of Product characterization
4. Results of dosing of different blends using different filling technologies
5. Summary
6. Conclusion
Key Words: Correlation of lactose qualities, blending and filling, Use of different qualities of lactose, Various blending parameters, Dosator, membrane filler and vacuum drum, Statistical evaluation of CPP
Abstract
This paper analyses the interaction between different compositions of blends and different filling technologies for inhalation powders. The blends consist of 1 basic coarse lactose plus 3 different fines in 3 different concentrations, resulting in a broad range of flowability. The blending parameters were kept constant. The blends were physically characterized and filled with 3 different dosing systems: dosator, vacuum drum and membrane filler. The filling results were statistically analyzed, and the Critical Process Parameter (CPP) was defined, if feasible. As expected, different dosing systems result in different most critical parameters of the blend characteristics. Therefore, different dosing systems can fill different powders: the vacuum drum can dose the full range of (inhalation) powders, the dosator can dose nearly everything except blends with too poor a flowability and the membrane filler reaches its limit when powder flowability is too good.
Correspondence:
Dr. Elke Sternberger-Rützel, Harro Höfliger Verpackungsmaschinen GmbH, Helmholtzstr. 4, 71573 Allmersbach i.T.; e-mail: elke.sternberger-ruetzel@hoefliger.de
Abstract
This paper analyses the interaction between different compositions of blends and different filling technologies for inhalation powders. The blends consist of 1 basic coarse lactose plus 3 different fines in 3 different concentrations,
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