High-Potency Pellet Microdosing Technology
A smart and easy way for production of low-dose active-ingredient capsules
Maschinen- und Anlagenbau
Abstract
This study demonstrates a reliable method for producing low-dose, high-potency pellets using Wurster coating technology. The pellets, layered with Ibuprofen as a model compound at doses as low as 0.1 mg, exhibit excellent flowability, uniformity, and high yield. Filling these into capsules allows precise, scalable dosing suitable for pediatric and neonatal use. The approach offers a safe, efficient, and industry-compatible solution for developing low-dose, age-appropriate pharmaceutical formulations which can be easily and precisely filled fully automatically into capsules by standard pellet dosing.
Correspondence:
Dr. Annette Grave
Glatt Pharmaceutical Services GmbH & Co. KG,
Werner‑Glatt‑Str. 1, 79589 Binzen
annette.grave@glatt.com
 | Dr. Annette Grave studied Pharmaceutical Sciences in Braunschweig and gained experience in a pharmacy and at Bayer Australia. She received her PhD in Pharmaceutical Technology from the University of Hamburg in 2003. She then joined Glatt in Binzen as a project manager and was Head of Pharmaceutical Development from 2009 until 2023. Since 2024, she has been working as Senior Scientific Expert |
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