Hypromellose-stabilisierte Emulsionen als Träger für homöopathische UrtinkturenChristian Wollenweber a, Rainer Oschmann b und Rolf Daniels c Deutsche Homöopathie Union a, Karlsruhe, Dr. Willmar Schwabe Arzneimittel b, Karlsruhe, und Institut für Pharmazeutische Technologie, Technische Universität Braunschweig c, Braunschweig Hypromellose-stabilized Emulsions as Vehicles for Homeopathic Mother Tinctures This paper deals with production and characterization of oil-in-water emulsions containing the homeopathic mother tincture Cardiospermum Halicacabum as active pharmaceutical ingredient. The aim of the examinations is the production of emulsions with low viscosity according to high stability during storage. To stabilize the emulsions different types of the polymeric emulsifier Hypromellose are used. The emulsions are prepared using rotor-stator-homogenization method in comparison high pressure homogenization method. The physico-chemical properties of the emulsions are characterized by measuring the interfacial tension between the oil and water phase and by determine emulsion viscosity. Emulsion droplet size was examined using laser diffraction method. Furthermore stability testing at different storage conditions were carried out. The investigations show that Hypromellose is a suitable polymeric emulsifier for emulsions containing Cardiospermum halicacabum mother tincture. The preparations can be applied as a dermal spray using a suitable applicator. In comparison with the Rotor-Stator-homogenization method, the high pressure homogenization method leads to more fine disperse emulsions indicating higher creaming stability. Facts up to now demonstrates storage stability of the emulsions for over twelve months at room temperature. Key words Cardiospermum Halicacabum-Urtinktur · Herstellungsmethode (Hochdruck- bzw. Rotor-Stator-Homogenisation) · Hypromellose · Lagerstabilität · Öl-in-Wasser-Emulsion |
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pharmind 2002, Nr. 1, Seite 81
