Kontinuierliche Feuchtgranulationsanlage auf Basis eines High-shear-Mischers
Pi Chi Chao, Klaus-Jürgen Steffens
Pharmazeutisches Institut, Rheinische-Friedrich-Wilhelms-Universität, Bonn
Corresponding author: Prof. Dr. Klaus-Jürgen Steffens, Rheinische Friedrich-Wilhelms-Universität Bonn, Pharmazeutisches Institut, Pharmazeutische Technologie, Gerhard-Domagk-Str. 3, 53121 Bonn (Germany), e-mail: steffens@uni-bonn.de
System for Continuous Wet Granulation based on a High-shear Mixer
A new system for continuous wet granulation and drying, based on a modified high-shear-mixer is investigated using metformine, paracetamole and ibuprofene as active ingredients. First experiments reveal the excellent shape and particle size distribution of the granules. Tabletting investigations show that under all conditions tablets of sufficient tensile strength can be produced, which are comparable to those granulated in a batch high-shear mixer. The system fulfils high-containment requirements and can be equipped with WIP/CIP components and sensors for particle size and water content.
Key words Continuous granulation • High containment • High-shear-granulator • Vacuum dryer • Wet granulation |
