Natural and Synthetic Phospholipids
For Vaccines and Other Complex Drug Delivery Systems – Part 2*)
Technik
Abstract
The applications of (phospho)lipid carriers in vaccines were discussed in Part 1 of the article. Part 2 focuses on the applications of (phospho)lipids in other complex drug delivery systems, in particular on depot injectables and pulmonary dosage forms. In depot injectables, (phospho)lipid-based drug carriers are successfully applied in marketed products in the form of complex multivesicular formulations and in situ, at the injection site, formed lipid depots. Research on further complex phospholipid-related depot injectables based on liposomes that aggregate in situ immediately before injection, and solid implants is ongoing. Also in pulmonary application phospholipids play, due to their biocompatibility with lung tissue, an important role in powders for inhalation, propellant formulations and liposomes. This part of the article describes recent advances achieved with phospholipid-based formulations for depot injectables and inhalation dosage forms.
Correspondence:
Dr. Peter Hölig
Lipoid GmbH, Frigenstr. 4, 67065 Ludwigshafen am Rhein
p.hoelig@lipoid.com
 | Dr. Richard Wibel is a pharmacist by training. In 2022, he obtained his PhD in Pharmaceutical Technology from the University of Innsbruck, Austria. Afterwards, he joined the business development section of Lipoid GmbH where he is responsible for the scientific marketing. |
 | PD Dr. Peter van Hoogevest is a pharmacist with PhD (biochemistry, Utrecht University, NL) and degree of Privatdozent in pharmacy (University of Basel, CH). |
