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Treatment of Particles with Low-flow Properties

János Bajdik, Klára Pintye-Hódi, Géza Regdon Jr., and István Eros

Department of Pharmaceutical Technology, University of Szeged, Szeged (Hungary)

The main problems which occur during the preparation of solid dosage forms (especially tablets and capsules) are the insufficient flow of the particles, poor compactibility and inadequate stability of the materials. The aim of preformulation, therefore, is to eliminate such problems, if possible. The effects of granulation and coating were examined. Dimenhydrinate was chosen as a model drug with low-flow properties and decomposition at the melting point. The shape of the particles and the flow properties (angle of repose, mass by volume, flow time, the Hausner factor and Carr‘s index) were determined. Differential scanning calorimetry was used to check the features of the sample on exposure to heat and to measure the melting point. The effect of the coating film on the melting point was observed during melting.

Key words Differential scanning calorimetry · Dimenhydrinate · Film coating · Hydroxypropylcellulose · Particles, agglomeration, flow properties · Solid dosage forms