Charakterisierung von Tablettensprengmitteln auf Stärkebasis
Originale
Key Words Carboxymethylstärke | Emcompress | Kartoffelstärke | Quellfähigkeit | Schmiermittel | Schmiermittelempfindlichkeit
Abstract
Characterization of Potato Starch Excipients as Tablet Disintegrants
The main objective of this study is to compare the disintegration properties of four frequently used excipients represented by three different sodium-carboxymethylstarches and potato starch. All disintegrants were premixed with calcium phosphate (EmcompressWz.) in various concentrations and lubricated with magnesium stearate. Biplane tablets were produced via direct compression.
All of the tablets obey the requirements of the European Pharmacopoeia regarding their disintegration times. Nevertheless the disintegration properties are closely related to the disintegrant used. Tablets made of carboxymethyl starches show an immediate swelling tendency resulting in shorter disintegration times. Potato starch is more sensitive towards magnesium stearate which leads to tablets with an optimized surface wettability and a decreased hygroscopicity.
Korrespondenz:
Priv.-Doz. Dr. Hubert Rein, Pharmazeutische Technologie, Rheinische Friedrich-Wilhelms-Universität, Gerhard-Domagk-Straße 3, 53121 Bonn-Endenich (Germany), e-mail: rein@uni-bonn.de
Zusammenfassung
Vier häufig verwendete Sprengmittel (drei unterschiedliche Natriumcarboxymethylstärken sowie Kartoffelstärke) wurden hinsichtlich ihrer zerfallsfördernden Eigenschaften untersucht. Dazu wurden diese in unterschiedlicher Konzentration mit Kalziumphosphat (EmcompressWz.) als Füllstoff und Magnesiumstearat als Schmiermittel zu biplanen Tabletten
