Feste Lösungen auf Stärkebasis am Beispiel von Tramadol·HCl Gabriel Wauer, Hubert Rein Rheinische Friedrich-Wilhelms-Universität, Bonn-Endenich (Germany) Korrespondenz: Dr. Hubert Rein, Rheinische Friedrich-Wilhelms-Universität, Pharmazeutische Technologie, Gerhard-Domagk-Str. 3, D-52121 Bonn-Endenich (Germany), e-mail: Rein@uni-bonn.de Solid Solutions of Tramadol·HCl based on Starch Starch-tramadol-extrudates were prepared using different starches as polymeric carrier to allow a sustained release of the drug. The hot melt extrusion process at higher temperatures than the gelatinization temperature was made on a single screw extruder. The used starch and the drug content influenced the retardation effect of the starch matrix. X-ray diffraction analysis and scanning electron microscopy of the drug containing extrudates show, that the starch and drug transformed into the amorphous state by the melt extrusion process to generate a solid solution. The glass transition temperature lowers with tramadol·HCl due to its plasticizer effect. Most of the starch matrices sustained the release of tramadol·HCl over 5–24 h depending on the amount of drug content and used starch. The results detailed in this paper showed, that starch is suitable filler for extended dosage forms. Key words Extrusion • Feste Lösung • Glasübergangstemperatur • Retardierung • Stärke • Tramadol·HCl |
|
|
pharmind 2010, Nr. 11, Seite 1973
