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Preparation of Pellets Containing Theophylline

Zsolt Musko a, Janos Bajdik a, Klara Pintye-Hodi a, Piroska Szabo-Revesz a, Andras Kelemen b, and Istvan Eros a

Department of Pharmaceutical Technology a, and Department of Medical Informatics b, University of Szege d, Szeged (Hungary)

The aim of this work was to prepare theophylline (CAS 5967-84-0) pellets by using a centrifugal granulator. Theophylline crystals have unsuitable powder rheological properties. Wet granulation was necessary and pellets with different particle sizes were prepared. The habit of the pellets was spherical, with a compact texture. The process of pellet deformation was tested by means of a modified equipment, and the forcetime curve is presented. Use of a centrifugal granulator with the parameters applied resulted in theophylline pellets with suitable parameters (shape, texture, deformation behaviour and dissolution). The particle size influenced the flow properties and the deformation parameters but it had no influence on the dissolution rate of active agent.