Hot Melt Technology1st Communication: Effect of Channeling Agents Part I: Granule characteristics Heba Guirgis a, Bianca Broegmann b, and Adel Sakr a Industrial Pharmacy Graduate Program, College of Pharmacy, University of Cincinnati a, Cincinnati, Ohio (USA), and Mundipharma GmbH b, Limburg (Germany) The effects of polyethylene glycol 4000 and various types of microcrystalline cellulose (MCC) on the characteristics of granules manufactured by the high shear hot melt technology were studied. Polyethylene glycol (PEG) 4000 was incorporated at various ratios in combination with cetostearyl alcohol (CSA; Lanette®) as hot melt excipients. MCC was incorporated extragranulary prior to compression of the CSA based granulations into tablets. It was found that PEG 4000 at the used concentrations did not have a significant effect on the granule characteristics. Depending on the MCC concentration, particle size and density there was a significant effect on flowability and density of the granulation. Key words Channeling agents · Granulation · Hot melt technology · Microcrystalline cellulose · Polyethylene glycol |
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pharmind 2001, Nr. 3, Seite 297
