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Influence of Sterilisation on a Sodium Carboxymethylcellulose Gel

Frank Jenne, Stefan Merkle, and Rainer Naeff The R. W. Johnson

Pharmaceutical Research Institute, a Division of Cilag AG, Schaffhausen (Switzerland)

Sterilisation of carboxymethylcellulose hydrogels were performed with different initial pressures and different gas atmospheres. It was found that the viscosity of the sterilised material is a function of the initial pressure and, to a greater extent, of the chemical nature of the gas. Rather than the sterilisation conditions, the added L-lysine-mono-hydrochloride had an influence on the viscosity of the sterilised gel. An analysis of the particle size of the sterilised gels with asymmetric flow field-flow fractionation (FFFF) showed only small differences in the size of the gel particles in spite of different viscosities.

Key words Carboxymethyl cellulose, field-flow fractionation, particle size distribution, sterilisation, viscosity