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Polarographic Behaviour and Determination of Benzydamine in Pharmaceutical Dosage Forms

Nahed M. El-Enany^a, Sheikha Al-Ghanam^b, and Fathalla Belal^a

Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura^a, Mansoura ( Egypt), and Department of Chemistry, Girls College of Science^b, Damam (Saudi Arabia)

A simple polarographic method is described for the determination of benzydamine in its pure form and different dosage forms. The proposed method depends upon the polarographic activity of benzydamine at the dropping mercury electrode in Britton-Robinson buffers, whereby, a well-defined cathodic wave was produced over the pH range 2-11. The waves were characterized as being irreversible diffusion-controlled with limited adsorption properties. In buffer of pH 9.0 the diffusion current constant, Id, is 4.58 + 0.048 (n = 8). The current-concentration relationship was found to be rectilinear over the range 3.4-34 and 0.34-27 µg/ml using direct current and differential pulse polarographic (DPP) modes, respectively, with minimum detection limit (S/N = 2) of 0.07 µg/ml (2 x 10^-7 mol/l) using DPP mode. The proposed method was applied to certain dosage forms including tablets, mouth-wash solutions, gel and cream. The average percent recoveries were favourably compared to those obtained by a reference method, with a satisfactory standard deviation. A proposal of the electrode reaction was postulated.

Key words Benzydamine, dosage forms, quantitative determination · CAS 132-69-4 · Polarography · Voltammetry