Polyols in the Development of Chewable Tablets Containing Magnesium AspartateHajnalka Göczo a, Piroska Szabo-Revesz a, Monika Pasztor-Turak b, Klara Pintye-Hodi a, Istvan Eros a, and György Dombi b University of Szeged, Department of Pharmaceutical Technology a and Department of Pharmaceutical Analysis b, Szeged (Hungary) Polyols are materials that are successfully used in many fields of the pharmaceutical industry in consequence of their favourable properties. This work reports on preformulation studies (particle size distribution, mass by volume and flowability) of different polyols (sorbitol, xylitol and mannitol) used as vehicles to produce chewable tablets containing magnesium aspartate by direct tabletting. The physical parameters (uniformity of mass, friability and crushing strength) and the magnesium content of tablets were determined. The magnesium content was measured by atomic absorption spectrometry. The results allow Pearlitol SD 200® and Neosorb P 20/60® to be suggested as filler and binder materials for the manufacture of chewable tablets. Key words Atomic absorption spectroscopy · Chewable tablets · Magnesium aspartate · Mannitol · Sorbitol · Xylitol
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pharmind 2001, Nr. 6, Seite 639
