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Comparison of Rotor Direct Pelletization (Fluid Bed) and Extrusion/Spheronization Method for Pellet Production

Robert Pisek a, Judita Sirca b, Gabrijela Svanjak c, and Stane Srcic c

Krka, d.d., Research and Development Division a, Novo mesto (Slovenia), Lek Pharmaceutical and Chemical Company d.d., Research and Development b, Ljubljana (Slovenia), and University of Ljubljana, Faculty of Pharmacy c, Ljubljana (Slovenia)

Comparison of extrusion/spheronization (single screw extruder and spheronizer) as the most popular method for the production of matrix pellets and rotor direct pelletization (smooth disc) as an alternative method was made. A complex method that involves many steps and different type of equipment was compared with a single pot method. A simple formulation of ketoprofen, microcrystalline cellulose (MCC) and lactose was used. The results show similarity in physicotechnological characteristics of produced pellets, only friability of pellets produced in rotor is significantly higher.

Key words Matrix pellets, characteristics, friability · Pelletization methods