Natural and Synthetic Phospholipids

Rubrik: Übersichten

(Treffer aus pharmind, Nr. 06, Seite 555 (2024))

Wibel R | van Hoogevest P | Hölig P

Natural and Synthetic Phospholipids / For Vaccines and Other Complex Drug Delivery Systems – Part 1 · Wibel R¹, van Hoogevest P², Hölig P¹ · ¹Lipoid GmbH, Ludwigshafen am Rhein und PHARMANOVATION Consulting, Rheinfelden (Baden)
Phospholipids Vaccines Depot injectables Pulmonary dosage forms All lipids that contain phosphorus are called phospholipids. Phospholipids are surface-active, amphiphilic molecules, which comprise a polar headgroup and a lipophilic tail. They can be found in any cell membrane and are therefore intrinsically biocompatible and biodegradable. The phospholipid molecule comprises a glycerol backbone, which is esterified in positions 1 and 2 with fatty acids and in position 3 with phosphate ( fig. 1 ). The systematic designation of, e.g. , phosphatidic acid (PA) is 1,2-diacyl- sn -glycero-3-phosphate (where sn means stereospecific numbering). The sn -2 carbon atom of glycerophospholipids is a chiral center, and natural ...